For Mixcraft 6 and under, no. Mixcraft 6 and under will only work with 32 bit plug-ins. Some people have installed 'Jbridge' which allows Mixcraft 6 and under to communicate with 64 bit plug-ins, which may work.
Also, most companies will also have a 32 bit version available, which is compatible with Mixcraft 6 and under.
Starting with Mixcraft 7, we offered an option to install 32-bit or 64-bit Mixcraft.
64-bit Mixcraft can load both 32- and 64-bit plugins with no special bridging software.
Mixcraft 9 has separate 32- and 64-bit installers.
Eric V
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